Popular Science asks, "Is it ethical to engineer delicious cows that feel no pain?" The answer is that of course it is; humanity has willfully modified animals through selective breeding and other means for all of recorded history. We've done this chiefly for our own purposes, but if we wished to do it for the benefit of the animal, there's certainly no reason we should not.
Now, my counter question: regardless of whether it is ethical, is it wise? These things weigh about a thousand pounds, give or take a few hundred for breed or sex. They're hard enough to control as it is. What are you going to do when they feel no pain?
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